Doxorubicin and Zidovudine interaction

Doxorubicin and Zidovudine: the Zidovudine prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Zidovudine label · effective 2026-01-19

Major

• Avoid use with doxorubicin.

Drug interactionsnames DoxorubicinView label on DailyMed
Major

Doxorubicin Concomitant use of zidovudine with doxorubicin should be avoided since an antagonistic relationship has been demonstrated in vitro.

Drug interactionsnames DoxorubicinView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.