Droperidol and Ropinirole interaction

Droperidol and Ropinirole: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Droperidol label · effective 2023-03-20

Moderate

Following the administration of droperidol, the dose of other CNS depressant drugs should be reduced.

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Minor

As with other CNS depressant drugs, patients who have received droperidol should have appropriate surveillance.

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From the Ropinirole label · effective 2026-01-16

Moderate

• Dopamine antagonists (e.g., neuroleptics, metoclopramide): May reduce efficacy of ropinirole.

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Moderate

Dopamine Antagonists Because ropinirole is a dopamine agonist, it is possible that dopamine antagonists such as neuroleptics (e.g., phenothiazines, butyrophenones, thioxanthenes) or metoclopramide may reduce the efficacy of ropinirole.

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Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.