Empagliflozin and Levothyroxine interaction

Empagliflozin and Levothyroxine: the Levothyroxine prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Levothyroxine (Levothyroxine Sodium) label · effective 2024-07-10

Moderate

Worsening of Diabetic Control : May worsen glycemic control and result in increased antidiabetic agent or insulin requirements.

Warnings and precautionsby drug classView label on DailyMed
Moderate

Worsening of Diabetic Control Addition of levothyroxine therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements.

Warnings and precautionsby drug classView label on DailyMed
Moderate

Antidiabetic Therapy Addition of levothyroxine to antidiabetic or insulin therapy may result in increased antidiabetic agent or insulin requirements.

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.