Emtricitabine, rilpivirine, and tenofovir and Hydrocodone and acetaminophen interaction
Emtricitabine, rilpivirine, and tenofovir and Hydrocodone and acetaminophen: the Emtricitabine, rilpivirine, and tenofovir prescribing label reports no clinically significant interaction between these two.
No clinically significant interaction reported. The label studied or considered this pair and found nothing meaningful.
What the FDA labels say
From the Emtricitabine, rilpivirine, and tenofovir (COMPLERA) label · effective 2025-07-16
No clinically significant drug interactions have been observed between RPV and the following medications: acetaminophen, atorvastatin, chlorzoxazone, ethinyl estradiol, ledipasvir/sofosbuvir, norethindrone, sildenafil, simeprevir, sofosbuvir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, or TDF.
Narcotic Analgesics : methadone ↓ R(–) methadone ↓ S(+) methadone ↔ RPV ↔ methadone (when used with tenofovir) No dose adjustments are required when initiating coadministration of methadone with COMPLERA.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.