Emtricitabine, rilpivirine, and tenofovir and Rabeprazole interaction
Emtricitabine, rilpivirine, and tenofovir and Rabeprazole: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Rabeprazole (Aciphex) label · effective 2026-01-27
PPIs, including ACIPHEX, are contraindicated with rilpivirine-containing products [see Drug Interactions (7) ] .
PPIs, including ACIPHEX delayed-release tablets, are contraindicated in patients receiving rilpivirine-containing products ( 4 , 7 ).
Intervention: Rilpivirine-containing products : Concomitant use with ACIPHEX delayed-release tablets is contraindicated [see Contraindications (4) ] .
Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with rabeprazole may reduce antiviral effect and promote the development of drug resistance.
Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with rabeprazole may increase toxicity.
From the Emtricitabine, rilpivirine, and tenofovir (COMPLERA) label · effective 2025-07-16
…phenobarbital, phenytoin Antimycobacterials: rifampin, rifapentine Glucocorticoid (systemic): dexamethasone (more than a single-dose) Herbal Products: St John's wort ( Hypericum perforatum ) Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole COMPLERA is contraindicated when coadministered with drugs which may…
Use of RPV with proton pump inhibitors is contraindicated and use of RPV with H 2 -receptor antagonists requires staggered administration [see Contraindications (4) and Clinical Pharmacology (12.3) ] .
Proton Pump Inhibitors: e.g., dexlansoprazole esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ RPV Coadministration is contraindicated due to potential for loss of virologic response and development of resistance.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.