Ephedrine and Ergotamine and caffeine interaction
Ephedrine and Ergotamine and caffeine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Ephedrine (Ephedrine Sulfate) label · effective 2026-03-17
• Pr e ssor Effect with Concomitant Oxytocic Drugs : Pressor effect of sympathomimetic pressor amines is potentiated (5.1)
From the Ergotamine and caffeine (Cafergot) label · effective 2026-03-23
Use with sympathomimetics (pressor agents) may cause extreme elevation of blood pressure.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.