Epinephrine and Isoproterenol interaction
Epinephrine and Isoproterenol: the Isoproterenol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Isoproterenol (Isoproterenol hydrochloride) label · effective 2026-03-17
Intervention Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously.
DRUG INTERACTIONS • Do not administer Isoproterenol Hydrochloride Injection and epinephrine simultaneously due to combined effects may induce serious arrhythmias ( 7 )
Table 1: Clinically Relevant Interactions with Isoproterenol Epinephrine Clinical Impact Both drugs are direct cardiac stimulants, and their combined effects may induce serious arrhythmias upon simultaneous administration.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.