Erlotinib and Ranitidine interaction
Erlotinib and Ranitidine: the Erlotinib prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Erlotinib label · effective 2024-06-26
Drugs the Increase Gastric pH Co-administration of erlotinib with proton pump inhibitors (e.g., omeprazole) and H-2 receptor antagonists (e.g., ranitidine) decreased erlotinib exposure [see Clinical Pharmacology (12.3) ].
For H-2 receptor antagonists and antacids, modify the dosing schedule [see Dosage and Administration (2.4) ].
For H-2 receptor antagonists, take erlotinib 10 hours after H-2 receptor antagonist dosing.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.