Escitalopram and Isoniazid interaction
Escitalopram and Isoniazid: the Escitalopram prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Escitalopram label · effective 2025-08-31
Escitalopram Capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, including linezolid or intravenous methylene blue, because of an increased risk of serotonin syndrome [see Dosage and Administration ( 2.6 ), Warnings and Precautions ( 5.2 ), Drug Interactions ( 7 )] .
Concomitant use of monoamine oxidase inhibitor (MAOI) or within 14 days of stopping an MAOI ( 4 , 5.2 , 7)
The concomitant use of Escitalopram Capsules with MAOIs is contraindicated.
Table 6: Clinically Important Drug Interactions with Escitalopram Capsules Monoamine Oxidase Inhibitors (MAOIs) Prevention or Management Escitalopram Capsules are contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration ( 2.6 ), Contraindications ( 4 ), Warnings and Precautions (…
Mechanism and Clinical Effect(s) Concomitant use of SSRIs, including Escitalopram Capsules, and MAOIs increases the risk of serotonin syndrome.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.