Estradiol and norethindrone and Phenobarbital interaction

Estradiol and norethindrone and Phenobarbital: the Estradiol and norethindrone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Estradiol and norethindrone (Estradiol / Norethindrone Acetate) label · effective 2026-06-26

Moderate

John's wort ( Hypericum perforatum ) preparations, phenobarbital, carbamazepine, and rifampin may reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile.

Drug interactionsnames PhenobarbitalView label on DailyMed

Minor

Inducers of CYP3A4 such as St.

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.