Estradiol and norethindrone and Rifabutin interaction

Estradiol and norethindrone and Rifabutin: both prescribing labels mention this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Estradiol and norethindrone (Estradiol / Norethindrone Acetate) label · effective 2026-06-26

Minor

Inducers of CYP3A4 such as St.

Drug interactionsby drug classView label on DailyMed

From the Rifabutin label · effective 2026-09-01

Minor

ND ↔ Ethinylestradiol (EE)/ Norethindrone (NE) 35 mg EE / 1 mg NE for 21 days 300 mg once a day for 10 days Healthy female subjects (22)

Drug interactionsnames Estradiol and norethindroneView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.