Estradiol and Topiramate interaction
Estradiol and Topiramate: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Moderate
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Topiramate (Trokendi XR) label · effective 2026-03-20
Moderate
Patients taking estrogen-containing or progestin-only contraceptives should be asked to report any change in their bleeding patterns.
From the Estradiol (Delestrogen) label · effective 2026-05-13
Minor
Inducers of CYP3A4 such as St.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.