Ethacrynic acid and Furosemide interaction
Ethacrynic acid and Furosemide: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Ethacrynic acid label · effective 2023-08-31
Like other diuretics it may precipitate hepatic coma and death.
A number of possibly drug-related deaths have occurred in critically ill patients refractory to other diuretics.
From the Furosemide label · effective 2026-05-13
Avoid concomitant use with ethacrynic acid.
Reports usually indicate that furosemide ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
• Ethacrynic acid : Risk of ototoxicity.
Ethacrynic acid Possibility of ototoxicity [see Warnings and Precautions (5.3) ] .
Monitor for changes in blood pressure and adjust the dose of other antihypertensive drugs if needed.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.