Etonogestrel and ethinyl estradiol and Lenacapavir interaction

Etonogestrel and ethinyl estradiol and Lenacapavir: the Etonogestrel and ethinyl estradiol prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Etonogestrel and ethinyl estradiol (Etonogestrel/Ethinyl Estradiol) label · effective 2025-02-26

Moderate

Concomitant administration of strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma estrogen and/or progestin concentrations.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.