Felbamate and Phenobarbital, hyoscyamine, atropine, and scopolamine interaction
Felbamate and Phenobarbital, hyoscyamine, atropine, and scopolamine: the Felbamate prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Felbamate (Felbatol) label · effective 2025-08-15
CBZ epoxide ↓ ↑ ↓ Phenobarbital ↑ ↓ Specific Effects of Felbatol® on Other Antiepileptic Drugs Phenytoin Felbatol ® causes an increase in steady-state phenytoin plasma concentrations.
Phenobarbital Coadministration of felbamate with phenobarbital causes an increase in phenobarbital plasma concentrations.
Phenobarbital It appears that phenobarbital may reduce plasma felbamate concentrations.
In 12 otherwise healthy male volunteers ingesting phenobarbital, the steady-state trough (C min ) phenobarbital concentration was 14.2 micrograms/mL.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.