Filgrastim and Plerixafor interaction
Filgrastim and Plerixafor: the Plerixafor prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Plerixafor (Mozobil) label · effective 2025-09-22
Hematologic Effects Leukocytosis Administration of Mozobil in conjunction with filgrastim increases circulating leukocytes as well as HSC populations.
Potential for Tumor Cell Mobilization: Tumor cells may be released from marrow during HSC mobilization with Mozobil and filgrastim.
Potential for Tumor Cell Mobilization When Mozobil is used in combination with filgrastim for HSC mobilization‚ tumor cells may be released from the marrow and subsequently collected in the leukapheresis product.
Cases of splenic enlargement and/or rupture have been reported following the administration of Mozobil in conjunction with filgrastim.
Evaluate individuals receiving Mozobil in combination with filgrastim who report left upper abdominal pain and/or scapular or shoulder pain for splenic integrity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.