Fosfomycin and Hydroxyzine interaction
Fosfomycin and Hydroxyzine: the Fosfomycin prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Fosfomycin (Contepo) label · effective 2025-11-04
Avoid co-administration of CONTEPO with drugs known to prolong the QT interval.
Avoid co-administration of CONTEPO with drugs known to prolong the QT interval, such as class IA or class III antiarrhythmic medications, tricyclic antidepressants, macrolides, and antipsychotics [see Warnings and Precautions ( 5.2 )] .
QT Prolongation: CONTEPO has been shown to prolong the QT interval in some patients in the clinical trial.
QT Prolongation CONTEPO has been shown to prolong the QT interval in some patients.
Drugs that prolong QT interval Co-administration of CONTEPO with other drugs known to prolong the QT interval may increase the risk for ventricular arrhythmia.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.