Fosinopril and hydrochlorothiazide and Mecamylamine interaction
Fosinopril and hydrochlorothiazide and Mecamylamine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Fosinopril and hydrochlorothiazide (Fosinopril Sodium and Hydrochlorothiazide) label · effective 2024-04-28
The thiazide component of fosinopril sodium and hydrochlorothiazide may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic-blocking drugs.
Fosinopril sodium and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives.
Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents.
From the Mecamylamine (Vecamyl) label · effective 2025-02-20
The action of Mecamylamine HCl may be potentiated by anesthesia, other antihypertensive drugs and alcohol.
When ganglion blockers or other potent antihypertensive drugs are discontinued suddenly, hypertensive levels return.
When Mecamylamine HCl is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.