Gabapentin and Sodium bicarbonate interaction
Gabapentin and Sodium bicarbonate: the Gabapentin prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Gabapentin (Neurontin) label · effective 2026-05-12
Maalox ® (aluminum hydroxide, magnesium hydroxide) The mean bioavailability of gabapentin was reduced by about 20% with concomitant use of an antacid (Maalox ® ) containing magnesium and aluminum hydroxides.
Antacid (Maalox ® ) (aluminum hydroxide, magnesium hydroxide) Antacid (Maalox ® ) containing magnesium and aluminum hydroxides reduced the mean bioavailability of gabapentin (N=16) by about 20%.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.