Ganciclovir and Imipenem and cilastatin interaction
Ganciclovir and Imipenem and cilastatin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Ganciclovir label · effective 2026-01-09
…Significant Drug Interactions with Ganciclovir for Injection Name of the Concomitant Drug Change in the Concentration of Ganciclovir or Concomitant Drug Clinical Comment Imipenem-cilastatin Unknown Coadministration with imipenem-cilastatin is not recommended because generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin.
• Imipenem-cilastatin: Seizures were reported in patients receiving ganciclovir and imipenem-cilastatin.
From the Imipenem and cilastatin (PRIMAXIN IV) label · effective 2024-07-05
Ganciclovir: Generalized seizures have been reported in patients who received ganciclovir.
Ganciclovir Generalized seizures have been reported in patients who received ganciclovir and PRIMAXIN.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.