Glyburide and metformin and Trospium interaction
Glyburide and metformin and Trospium: the Trospium prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Trospium (TROSPIUM CHLORIDE) label · effective 2026-08-05
Concomitant use with metformin immediate release tablets reduced exposure and peak concentration of trospium.
Metformin Co-administration of 500 mg metformin immediate release tablets twice daily reduced the steady-state systemic exposure of trospium by approximately 29% for mean AUC (0-24) and by 34% for mean C max .
The effect of metformin at higher doses on trospium PK is unknown [see Clinical Pharmacology ( 12.3 )].
The steady-state pharmacokinetics of metformin were comparable when administered with or without 60 mg trospium chloride extended-release capsules once daily under fasted condition.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.