Granisetron and Ketoconazole interaction

Granisetron and Ketoconazole: the Granisetron prescribing label mentions this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Granisetron (Granisetron Hydrochloride) label · effective 2025-04-24

Minor

In in vitro human microsomal studies, ketoconazole inhibited ring oxidation of granisetron hydrochloride.

Drug interactionsnames KetoconazoleView label on DailyMed
Minor

However, the clinical significance of in vivo pharmacokinetic interactions with ketoconazole is not known.

Drug interactionsnames KetoconazoleView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.