Grapefruit and Palbociclib interaction
Grapefruit and Palbociclib: the Palbociclib prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Major
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Palbociclib (Ibrance) label · effective 2026-07-02
Major
Avoid grapefruit or grapefruit juice during IBRANCE treatment.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.