Haloperidol and Lumateperone interaction
Haloperidol and Lumateperone: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Lumateperone (CAPLYTA) label · effective 2025-06-20
Agranulocytosis (including fatal cases) has been reported with other antipsychotic drugs.
Seizures Like other antipsychotic drugs, CAPLYTA may cause seizures.
Potential for Cognitive and Motor Impairment CAPLYTA, like other antipsychotics, may cause somnolence and has the potential to impair judgment, thinking, and motor skills.
From the Haloperidol (Haloperidol Decanoate) label · effective 2025-02-19
An increased risk cannot be excluded for haloperidol decanoate, other antipsychotics, or other patient populations.
As with other antipsychotic agents, it should be noted that haloperidol may be capable of potentiating CNS depressants such as anesthetics, opioids, and alcohol.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.