Hydrochlorothiazide and Piperacillin and tazobactam interaction
Hydrochlorothiazide and Piperacillin and tazobactam: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Hydrochlorothiazide (INZIRQO) label · effective 2025-12-16
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.
From the Piperacillin and tazobactam (Piperacillin and Tazobactam and Sodium Chloride) label · effective 2026-05-08
Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.