Hydrocodone and chlorpheniramine and Paroxetine interaction
Hydrocodone and chlorpheniramine and Paroxetine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Hydrocodone and chlorpheniramine (Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release) label · effective 2025-06-26
Serotonergic drugs : Concomitant use may result in serotonin syndrome.
Avoid the use of Hydrocodone Polistirex and Chlorpheniramine Polistirex while taking a CYP3A4 or CYP2D6 inhibitor.
The use of MAOIs or tricyclic antidepressants with hydrocodone, one of the active ingredients in Hydrocodone Polistirex and Chlorpheniramine Polistirex, may increase the effect of either the antidepressant or hydrocodone.
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.
From the Paroxetine (PAROXETINE HYDROCHLORIDE) label · effective 2026-09-16
Examples Other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, St.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.