Hydroxychloroquine and Praziquantel interaction

Hydroxychloroquine and Praziquantel: the Hydroxychloroquine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Hydroxychloroquine (Plaquenil) label · effective 2026-04-09

Moderate

Praziquantel Chloroquine has been reported to reduce the bioavailability of praziquantel.

Drug interactionsnames PraziquantelView label on DailyMed
Minor

Interaction of praziquantel with hydroxychloroquine cannot be ruled out.

Drug interactionsnames PraziquantelView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.