Ifosfamide and Phenytoin interaction
Ifosfamide and Phenytoin: the Ifosfamide prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Ifosfamide (IFEX) label · effective 2024-12-02
• CYP3A4 Inducers: Monitor for increased toxicity when used in combination with CYP3A4 inducers.
Inducers of CYP3A4 CYP3A4 inducers may increase the metabolism of ifosfamide to its active alkylating metabolites.
CYP3A4 inducers may increase the formation of the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde.
Closely monitor patients taking ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.