Imatinib and Meclizine interaction
Imatinib and Meclizine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Imatinib (Gleevec) label · effective 2026-07-13
In these instances, Gleevec was resumed at a dose lower than that at which the reaction occurred and some patients also received concomitant treatment with corticosteroids or antihistamines.
From the Meclizine (Meclizine Hydrochloride) label · effective 2026-06-12
• CYP2D6 inhibitors: As meclizine is metabolized by CYP2D6, there is a potential for drug-drug interactions between meclizine hydrochloride and CYP2D6 inhibitors ( 7.2 ).
CYP2D6 Inhibitors Based on in-vitro evaluation, meclizine is metabolized by CYP2D6.
Therefore, there is a possibility for a drug interaction between meclizine hydrochloride and CYP2D6 inhibitors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.