Indapamide and Sulfamethoxazole and trimethoprim interaction
Indapamide and Sulfamethoxazole and trimethoprim: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Indapamide label · effective 2026-05-13
Known hypersensitivity to indapamide or to other sulfonamide-derived drugs.
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-01-05
Drug Interactions In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.