Indomethacin and Sulfamethoxazole and trimethoprim interaction
Indomethacin and Sulfamethoxazole and trimethoprim: the Sulfamethoxazole and trimethoprim prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Moderate
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-01-05
Moderate
Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.