Iron and Methyldopa interaction
Iron and Methyldopa: the Methyldopa prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Methyldopa label · effective 2025-03-28
Coadministration of methyldopa with ferrous sulfate or ferrous gluconate is not recommended.
Several studies demonstrate a decrease in the bioavailability of methyldopa when it is ingested with ferrous sulfate or ferrous gluconate.
Curated guidance for Iron
Iron reduces the absorption of these medicines; take them a few hours apart.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.