Isoflurane and Nifedipine interaction

Isoflurane and Nifedipine: the Isoflurane prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Isoflurane (FORANE) label · effective 2024-12-09

Moderate

Calcium Antagonists FORANE may lead to marked hypotension in patients treated with calcium antagonists.

Drug interactionsby drug classView label on DailyMed

Minor

FORANE can induce malignant hyperthermia in patients with known or suspected susceptibility based on genetic factors or family history, including those with certain inherited ryanodine receptor ( RYR1 ) or dihydropyridine receptor ( CACNA1S ) variants [see Contraindications (4) , Clinical Pharmacology (12.5) ] .

Warnings and precautionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.