Isosorbide dinitrate and hydralazine and Nitroglycerin interaction
Isosorbide dinitrate and hydralazine and Nitroglycerin: the Nitroglycerin prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Nitroglycerin (NITROGLYCERIN LINGUAL) label · effective 2025-12-17
Hypersensitivity to Nitroglycerin Lingual Spray or to other nitrates or nitrites or any excipient.
Hypersensitivity Nitroglycerin Lingual Spray is contraindicated in patients who are allergic to nitroglycerin, other nitrates or nitrites or any excipient.
Antihypertensives: Possible additive hypotensive effects.
Antihypertensives Patients receiving antihypertensive drugs, beta-adrenergic blockers, and nitrates should be observed for possible additive hypotensive effects.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.