Itraconazole and Norethindrone and ethinyl estradiol interaction
Itraconazole and Norethindrone and ethinyl estradiol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Itraconazole (Tolsura) label · effective 2025-04-23
Contraceptives Dienogest Ulipristal Monitor for adverse reactions.
From the Norethindrone and ethinyl estradiol (Lo Loestrin Fe) label · effective 2025-03-07
CYP3A4 inhibitors such as itraconazole or ketoconazole may increase plasma hormone levels.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.