Ketoconazole and Losartan interaction
Ketoconazole and Losartan: the Losartan prescribing label report no clinically significant interaction between these two.
No interaction
No clinically significant interaction reported. The label studied or considered this pair and found nothing meaningful.
What the FDA labels say
From the Losartan (COZAAR) label · effective 2026-01-20
No interaction
Conversion of losartan to its active metabolite after intravenous administration is not affected by ketoconazole, an inhibitor of P450 3A4.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.