Ketoprofen and Orphenadrine, aspirin, and caffeine interaction
Ketoprofen and Orphenadrine, aspirin, and caffeine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Orphenadrine, aspirin, and caffeine (Norgesic) label · effective 2026-01-08
Pregnancy Embryo-Fetal Toxicity Inform pregnant women to avoid use of aspirin and other NSAIDs starting at 30 weeks gestation because of the risk of the premature closing of the fetal ductus arteriosus.
Data from observational studies regarding other potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive.
From the Ketoprofen label · effective 2026-04-02
Throughout this package insert, the term NSAID refers to a non-aspirin non-steroidal anti-inflammatory drug.
Ketoprofen Capsules, USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal.
This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs (see CONTRAINDICATIONS and PRECAUTIONS, Preexcisting Ashma ).
Since cross reactivity, including bronchospasm, between aspirin and other non-steroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, Ketoprofen Capsules, USP should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.