Ketorolac and Pentoxifylline interaction
Ketorolac and Pentoxifylline: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Ketorolac (Ketorolac Tromethamine) label · effective 2024-12-31
The concomitant use of ketorolac tromethamine and pentoxifylline is contraindicated.
Pentoxifylline When ketorolac tromethamine is administered concurrently with pentoxifylline, there is an increased tendency to bleeding.
From the Pentoxifylline label · effective 2026-05-15
DRUG INTERACTIONS Bleeding has been reported in patients treated with pentoxifylline extended-release tablets with or without concomitant NSAIDs, anticoagulants, or platelet aggregation inhibitors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.