Levalbuterol and Sotalol interaction
Levalbuterol and Sotalol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Levalbuterol (XOPENEX HFA) label · effective 2025-06-02
In this setting, cardioselective beta-blockers should be considered, although they should be administered with caution.
Beta-blockers : May block bronchodilatory effects of beta-agonists and produce severe bronchospasm.
Patients with asthma should not normally be treated with beta-blockers.
Beta-blockers Beta-blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-adrenergic agonists, such as XOPENEX HFA, but may produce severe bronchospasm in asthmatic patients.
Therefore, patients with asthma should not normally be treated with beta-blockers.
From the Sotalol (Sotalol hydrochloride) label · effective 2025-07-31
Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.
Antagonizes effect of beta-agonists ( 7.6 )
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.