Levetiracetam and Warfarin interaction

Levetiracetam and Warfarin: the Levetiracetam prescribing label mention this combination without an instruction to avoid it or change the dose.

Minor

Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.

What the FDA labels say

From the Levetiracetam label · effective 2024-03-15

Minor

Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studies (phenytoin, valproate, warfarin, digoxin, oral contraceptive, probenecid) and through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.

Drug interactionsnames WarfarinView label on DailyMed
Minor

Warfarin Levetiracetam (1000 mg twice daily) did not influence the pharmacokinetics of R and S warfarin.

Drug interactionsnames WarfarinView label on DailyMed
No interaction

Coadministration of warfarin did not affect the pharmacokinetics of levetiracetam.

Drug interactionsnames WarfarinView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.