Lisinopril and Lithium interaction

Lisinopril and Lithium: the Lisinopril prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Lisinopril (Zestril) label · effective 2025-01-02

Moderate

Lithium: Symptoms of lithium toxicity ( 7.5 )

Drug interactionsnames LithiumView label on DailyMed
Moderate

Lithium Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs, which cause elimination of sodium, including ACE inhibitors.

Drug interactionsnames LithiumView label on DailyMed
Moderate

Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor.

Drug interactionsnames LithiumView label on DailyMed
Moderate

Monitor serum lithium levels during concurrent use.

Drug interactionsnames LithiumView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.