Lithium and Perindopril interaction

Lithium and Perindopril: the Perindopril prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Perindopril (Perindopril Erbumine) label · effective 2024-03-13

Moderate

Lithium: Increase serum lithium levels, symptoms of lithium toxicity.

Drug interactionsnames LithiumView label on DailyMed
Moderate

Lithium Increased serum lithium and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy.

Drug interactionsnames LithiumView label on DailyMed
Moderate

Frequent monitoring of serum lithium concentration is recommended.

Drug interactionsnames LithiumView label on DailyMed
Moderate

Use of a diuretic may further increase the risk of lithium toxicity.

Drug interactionsnames LithiumView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.