Lithium and Sacubitril and valsartan interaction
Lithium and Sacubitril and valsartan: the Sacubitril and valsartan prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sacubitril and valsartan (ENTRESTO) label · effective 2026-07-06
Lithium: Increased risk of lithium toxicity.
Lithium Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists.
Monitor serum lithium levels during concomitant use with ENTRESTO.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.