Lithium and Sodium polystyrene sulfonate interaction

Lithium and Sodium polystyrene sulfonate: the Sodium polystyrene sulfonate prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Sodium polystyrene sulfonate label · effective 2025-05-27

Moderate

Decreased absorption of lithium and thyroxine have also been reported with co-administration of Sodium Polystyrene Sulfonate Powder, for Suspension.

Drug interactionsnames LithiumView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.