Lofexidine and Voriconazole interaction
Lofexidine and Voriconazole: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Lofexidine label · effective 2026-07-22
Risk of QT Prolongation : Lofexidine tablets prolong the QT interval.
Risk of QT Prolongation Lofexidine tablets prolong the QT interval.
Methadone : Methadone and Lofexidine tablets both prolong the QT interval.
Methadone Lofexidine tablets and methadone both prolong the QT interval.
From the Voriconazole label · effective 2026-06-02
Eszopiclone (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased which may Increase the Sedative Effect of Eszopiclone Dose reduction of eszopiclone is recommended.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.