Metformin and Prednisone interaction
Metformin and Prednisone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Prednisone (Prednisone delayed release) label · effective 2026-04-30
Antidiabetic agents: May increase blood glucose concentrations.
Dose adjustments of antidiabetic agents may be required.
Antidiabetic Agents Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.
From the Metformin (Metformin hydrochloride) label · effective 2024-11-14
Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.