Methadone and Zidovudine interaction
Methadone and Zidovudine: the Methadone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Moderate
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Methadone (METHADOSE) label · effective 2026-04-27
Moderate
Zidovudine Experimental evidence demonstrated that methadone increased the AUC of zidovudine which could result in toxic effects.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.