Methazolamide and Metoprolol and hydrochlorothiazide interaction

Methazolamide and Metoprolol and hydrochlorothiazide: the Metoprolol and hydrochlorothiazide prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Metoprolol and hydrochlorothiazide (METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE) label · effective 2025-01-22

Major

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs.

Contraindicationsby drug classView label on DailyMed
Major

Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or other sulfonamide-derived drugs.

Contraindicationsby drug classView label on DailyMed
Moderate

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

Warnings and precautionsby drug classView label on DailyMed
Minor

Acute Myopia and Second Angle-Closure Glaucoma Hydrochlorothiazide, a sulfonamide, can cause acute transient myopia and acute angle-closure glaucoma (idiosyncratic reactions).

Warnings and precautionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.