Methimazole and Tranylcypromine interaction
Methimazole and Tranylcypromine: the Tranylcypromine prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tranylcypromine (Tranylcypromine Sulfate) label · effective 2025-07-25
People who have thyroid problems (hyperthyroidism) may have a higher chance of having a hypertensive crisis.
…conditions, including if you: have high or low blood pressure have heart problems have cerebrovascular problems or have had a stroke have headaches have, or have a family history of, bipolar disorder, mania, or hypomania plan to have surgery have liver or thyroid problems have or have had seizures or convulsions have diabetes are pregnant or plan to become pregnant.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.