Methyldopa and Spironolactone and hydrochlorothiazide interaction
Methyldopa and Spironolactone and hydrochlorothiazide: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Spironolactone and hydrochlorothiazide label · effective 2026-02-10
Thiazides may add to or potentiate the action of other antihypertensive drugs.
From the Methyldopa label · effective 2025-03-28
Drug Interactions When methyldopa is used with other antihypertensive drugs, potentiation of antihypertensive effect may occur.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.